What is pretibial Myxoedema?

Pretibial myxedema or localized myxedema or thyroid dermopathy is an autoimmune manifestation of Graves’ disease. It also occasionally occurs in Hashimoto’s thyroiditis. Lesions of thyroid dermopathy are usually asymptomatic and have only cosmetic importance.

Is pretibial Myxoedema pitting?

It is usually asymptomatic and more of a cosmetic concern, but can be itchy or sore. Early lesions are bilateral, firm, non-pitting, asymmetrical plaques or nodules; they may coalesce to form scaly, thickened and hardened skin areas.

How is pretibial Myxoedema treated?

Surgical treatment should be avoided because scarring may aggravate the dermopathy, and benefits are equivocal. Local application of corticosteroids remains the mainstay of treatment. Compression wraps or stockings that provide 20-40 mm Hg of pressure can be useful as an adjunctive therapy.

What is Myxoedema look like?

Symptoms of myxedema include thickening of the skin and other symptoms associated with hypothyroidism, including fatigue, weight gain, depression, dry skin, and brittle hair, among others. Skin thickening or swelling associated with myxedema is often described as nonpitting edema.

What is pretibial?

Medical Definition of pretibial : lying or occurring anterior to the tibia a pretibial skin rash.

What is the difference between Pretibial myxedema and myxedema?

In this latter sense, myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area. One manifestation of myxedema occurring in the lower limb is pretibial myxedema, a hallmark of Graves disease, an autoimmune form of hyperthyroidism.

What is the cause of Pretibial myxedema?

Pretibial myxedema (PTM) occurs as a result of the deposition of hyaluronic acid in the dermis and subcutis. The precise cause of this phenomenon remains uncertain.

What Graves dermopathy looks like?

Nippoldt, M.D. Rarely, people with Graves’ disease develop Graves’ dermopathy, a skin condition characterized by red, swollen skin, usually on the shins and tops of the feet. The texture of the affected skin may be similar to that of an orange peel. Doctors may also refer to the condition as pretibial myxedema.

What causes Pretibial myxedema?

Is pretibial myxedema hypothyroidism?

Pretibial myxedema (PM) is an infiltrative dermopathy which is seen in grave’s disease. It is also associated with hypothyroidism, but is infrequently seen in Hashimoto’s thyroiditis. Lesions are seen commonly over pretibial region as non-pitting oedema or with a plaque morphology.

What is the difference between pretibial myxedema and myxedema?

What do you need to know about pretibial myxedema?

Pretibial Myxedema. PTM. Pretibial myxedema, which is also known as infiltrative dermopathy, is a thyroid dermopathy characterized by the development of abnormallly thick and waxy skin over the shin. It occurs almost exclusively secondary to Grave’s disease, an autoimmune cause of hyperthyroidism.

What kind of thyroid disease does pretibial myxedema occur in?

Pretibial myxedema is nearly always associated with autoimmune thyroid disease, that is Graves disease. Pretibial myxedema occurs in 0.5-4.3% of patients with Graves disease.

Which is a glycosaminoglycan in pretibial myxedema?

The main glycosaminoglycan in pretibial myxedema is hyaluronic acid, which is made by cells called the fibroblasts. Pretibial myxedema has also been reported, but much less frequently, in patients with Hashimoto thyroiditis, primary hypothyroidism, and euthyroidism. Peak incidence occurs in the fifth to sixth decades of life.

Which is rare, Graves disease or pretibial myxedema?

Pretibial myxedema (myxoedema (UK), also known as Graves’ dermopathy, thyroid dermopathy, Jadassohn-Dösseker disease or Myxoedema tuberosum) is an infiltrative dermopathy, resulting as a rare complication of Graves’ disease, with an incidence rate of about 1-5%. 1 Signs and symptoms.