What reaction is glucose-6-phosphate dehydrogenase catalyzed?

Glucose-6-phosphate dehydrogenase (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types. The enzyme catalyses the the first step in the pentose pathway: the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH.

Which of the following is used by the glucose 6-phosphate dehydrogenase enzyme to Catalyse its reaction?

G6PD (EC 1.1. 1.49) is the first enzyme of the anabolic pentose phosphate pathway that catalyzes the oxidation of glucose 6-phosphate (G6P) into 6-phosphoglucoo-δ-lactone by reducing NADP+ or NAD+.

What does g6p dehydrogenase do?

This enzyme helps protect red blood cells from damage and premature destruction. Glucose-6-phosphate dehydrogenase is responsible for the first step in the pentose phosphate pathway, a series of chemical reactions that convert glucose (a type of sugar found in most carbohydrates) to another sugar, ribose-5-phosphate.

What kind of enzyme is glucose 6 phosphate dehydrogenase?

Glucose-6-phosphate dehydrogenase. Not to be confused with Glucose 6-phosphatase. Glucose-6-phosphate dehydrogenase ( G6PD or G6PDH) ( EC 1.1.1.49) is a cytosolic enzyme that catalyzes the chemical reaction. This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells

How is glutathione produced by glucose 6 phosphate dehydrogenase?

Glucose-6-phosphate dehydrogenase deficiency. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the RBC hexose monophosphate pathway designed to produce reduced glutathione.14 Glutathione is used to prevent oxidative damage to hemoglobin and other intracellular structures.

How is G6PD deficiency related to hemolysis of red blood cells?

General Discussion. Summary. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic metabolic abnormality caused by deficiency of the enzyme G6PD. This enzyme is critical for the proper function of red blood cells: when the level of this enzyme is too low, red blood cells can break down prematurely (hemolysis).

What happens to a person with glucose 6 phosphate deficiency?

Most have a mild to moderate anemia, but severe, transfusion-dependent anemia can develop. Affected individuals can potentially develop severe complications such as hypovolemic shock. In rare cases, severe acute hemolysis has led to acute kidney failure.