What does IL-23 stimulate?
Interleukin-23 (IL-23) is a member of the IL-12 family of cytokines with pro-inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 (Th17) cells indicates the responsibility for many of the inflammatory autoimmune responses.
What is IL-23 protein?
Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. IL-23 is produced by dendritic cells and macrophages. Interleukin-23 is a heterodimeric cytokine composed of an IL-12p40 subunit that is shared with IL-12 and the IL-23p19 subunit.
What cell type expresses IL-23?
IL-23 imbalance and increase is associated with autoimmune and cancerous diseases. It is thus a target for therapeutic research. IL-23 expressed by dendritic cells is further induced by thymic stromal lymphopoietin – a proallergic cytokine expressed by keratinocytes which is elevated in psoriatic lesions.
Does Th17 produce IL-23?
While the requirement for IL-23 in the function of Th17 cells in vivo is established, the precise role of this cytokine in affecting the Th17 phenotype is unclear. Among other functions, IL-23 was proposed to act as a Th17 cell proliferation or survival factor.
How is IL-23 produced?
IL-23 is produced primarily by activated macrophages and dendritic cells (DCs). It expands Th17 cells and maintains their phenotype such as their cytokine production including IL-17A, which is their major effector molecule15.
What is the difference between IL-17 and IL-23?
Both IL-17 and IL-23 are implicated in PsA pathogenesis; however, IL-17-mediated inflammation may be more central in the development of cardiometabolic comorbidities and axial spondyloarthritis, whereas IL-23 may be more important in IBD immunopathogenesis.
What do Th17 cells do?
Th17 cells prevent severe HIV infection by maintaining the intestinal epithelial barrier during HIV infection in the gut. Because of their high levels of CCR5 expression, the coreceptor for HIV, they are preferentially infected and depleted. Thus, it is through Th17 cell depletion that microbial translocation occurs.
Who discovered IL-23?
IL-23. IL-23 was discovered by Oppmann et al. in 2000 [27]. It is a cytokine that induces the differentiation of naive CD4+ T cells into Th17 cells and has become an important therapeutic target for the treatment of a number of chronic immune-inflammatory disorders [28].
What is the crystal structure of interleukin 23?
Interleukin 23. Jump to navigation Jump to search. Crystal structure of IL-12B. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an IL12B (IL-12p40) subunit (that is shared with IL12) and the IL23A (IL-23p19) subunit.
How is IL-23 produced in innate lymphoid cells?
Innate lymphoid cells and also gamma delta T cells also produce IL-23. B cells produces IL-23 through BCR signaling. Secretion is stimulated by an antigen stimulus recognised by a pattern recognition receptor. IL-23 imbalance and increase is associated with autoimmune and cancerous diseases.
What is the function of interleukin 23 in Th17?
IL-23 stabilises RORγt and thus enables Th17 to properly function and release their effector cytokines such as IL-17, IL-21, IL-22 and GM-CSF which mediate protection against extracellular parasites (fungi and bacteria) and participate in barrier immunity.
How is IL-23 used to treat cardiovascular disease?
IL-23 can also make progression of cardiovascular disease as atherosclerosis, hypertension, aortic dissection, cardiac hypertrophy, myocardial infarction and acute cardiac injury. IL-23 is one of the therapeutic targets to treat the inflammatory diseases.
