How does VKORC1 affect warfarin?

Warfarin exerts its anticoagulant effect by inhibiting the enzyme encoded by VKORC1, which catalyzes the conversion of vitamin K epoxide to the active reduced form of vitamin K, vitamin K hydroquinone.

What is CYP2C9 warfarin?

CYP2C9 is the primary enzyme responsible for inactivating warfarin. The CYP2C9*3 variant allele has been shown to cause an 80% decrease in enzymatic activity of CYP2C9 and therefore contributes to the dose variance of warfarin [4.

What is CYP2C9 gene?

The CYP2C9 gene provides instructions for making an enzyme that is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. The CYP2C9 enzyme breaks down (metabolizes) compounds including steroid hormones and fatty acids.

What are the effects of VKORC1 c-1693g polymorphism?

Possession of CYP2C9*2 and/or CYP2C9*3 allele variants is associated with lower time of international normalized ratio (INR) in the therapeutic range (TTR) values and warfarin dose variations in aortic valve replacement patients, the latter affected also by VKORC1 c.-1693G>A polymorphism

What is the effect of VKORC1 on warfarin responsiveness?

The effect of the VKORC1 promoter variant on warfarin responsiveness in the Saudi WArfarin Pharmacogenetic (SWAP) cohort. Algorithm for predicting low maintenance doses of warfarin using age and polymorphisms in genes CYP2C9 and VKORC1 in Brazilian subjects.

How are CYP4F2 and VKORC1 polymorphisms related to carotid plaque formation?

CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation. Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact. Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.

Which is better for DVT VKORC1 or CYP4F2?

The VKORC1 (-1693 G>A) AA genotype was associated with fewer cases of DVT (odds ratio = 0.435; 95% confidence interval 0.205-0.991; P = .031). This study provides data on VKORC1 and CYP4F2 variants among an indigenous Ghanaian population.