What causes dog ototoxicity?
A variety of drugs and chemicals are ototoxic and vestibulotoxic, especially the aminoglycoside antibiotics (gentamicin, amikacin), antineoplastic drugs (cisplatin), salicylates, diuretics (ethacrynic acid, furosemide), and antiseptics (chlorhexidine). The damage from toxicity is usually permanent.
Which drug produces ototoxicity?
Ototoxic drugs include antibiotics such as gentamicin, streptomycin, tobramycin, loop diuretics such as furosemide and platinum-based chemotherapy agents such as cisplatin and carboplatin. A number of nonsteroidal anti-inflammatory drugs (NSAIDS) have also been shown to be ototoxic.
What is dog ototoxicity?
Ototoxicity can be defined as the capacity of certain drugs or chemicals to damage inner ear structures, including the cochlea, the vestibule and the semicircular canals and/or inner ear function1. This can result in either hearing impairment and/or vestibular dysfunction (peripheral vestibular ataxia).
Why has my dog suddenly gone deaf?
Deafness may be caused by a number of factors, including congenital defects, chronic ear infections, head injuries, drug toxicity, degenerative nerve changes, old age or disease, such as a tumor or ruptured ear drum. In addition to wax buildup, some dogs may have excess hair in or around their ears.
What is gentamicin?
Gentamicin injection is used to treat serious bacterial infections in many different parts of the body. Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.
Can Baytril cause deafness in dogs?
Baytril Otic is a liquid emulsion that is used topically directly in the ear or on the skin in order to treat susceptible bacterial and yeast infections. Most pets experience no problems. However, hearing loss, balance disorders and increased redness of the ear are possible. Other side effects may occur.
Is neomycin an ototoxic?
Neomycin is very toxic to the hearing part of the inner ear. Some of the solvents for the antibiotics have also been reported as being ototoxic. Propylene glycol is an example (Morizono et al, 1980). As you can see below, numerous commonly used ear preparations contain these drugs.
Do dogs know when they are deaf?
Remember, a dog born deaf doesn’t know it’s missing anything! It has no frame of reference to know what hearing is. A deaf dog may think its hearing playmate is more observant, but many times a deaf dog’s vision and sense of smell will more than make up for what its ears miss.
Can ear wax cause deafness in dogs?
Laura Derrington advises in The Structure of Dog Ears, “Excessive ear wax can cause temporary hearing loss, especially in breeds with narrow ear canals, such as poodles. If a dog has a lot of hair around its ear, the ear canal can get blocked.
Are there dog ear drops that are ototoxic?
Ototoxic Dog Ear Drops Several ear drops containing aminoglycoside antibiotics can be ototoxic in both humans and pets. These drugs are often used to treat different types of bacterial infections and they are mostly administered by injection or topically, directly into the ear under ear drops and ointments.
What kind of drugs can cause deafness in dogs?
“Drugs that are more frequently incriminated include neomycin, propylene glycol, and tobramycin, but many other drugs have been incriminated,” he says. After the drug has worn off, the dog may return to normal hearing, but ototoxicity can also lead to permanent deafness.
Are there any ototoxic medications for dogs with Baer?
Conversely, topical medications which were found to suppress BAER in dogs (ie. were ototoxic) included 1% tobramycin, 2.5% ticarcillin,2 DSS, carbamide peroxide, and triethanolamine. 4 The literature in cats is even more sparse.
Which is the most common ototoxic agent in veterinary medicine?
The best recognized, and perhaps most frequent, agents of ototoxicity in veterinary medicine are the aminoglycoside antibiotics, especially gentamicin, but polypeptides, chloramphenicol, erythromycin, and (oxy)tetracycline are ototoxic as well 3.
