What is NF1 disease?

Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumours to grow along your nerves. The tumours are usually non-cancerous (benign) but may cause a range of symptoms. Neurofibromatosis type 2 (NF2) is much less common than NF1.

What is tibial dysplasia?

Tibial dysplasia involves excessive bowing or curvature of the tibia (also called the shin bone). If tibial dysplasia is suspected and confirmed through an X-ray, a child should be referred to an orthopedist for care focused on the prevention and management of fractures.

What is innominate line?

The innominate line is a projection of the greater wing of the sphenoid, and its absence or destruction is responsible for this appearance. It is the classical frontal radiograph sign of neurofibromatosis type I (NF1).

Is NF2 genetic?

Neurofibromatosis type 2 (NF2) is a genetic condition that causes tumours to grow along your nerves. The tumours are usually non-cancerous (benign) but may cause a range of symptoms. Neurofibromatosis type 1 (NF1) is covered separately because it has different symptoms and causes. It’s also much more common than NF2.

Can diet help NF1?

These data link NF1 deficiency to fundamental shifts in muscle metabolism, and provide strong proof of principal that a dietary intervention can ameliorate symptoms.

How does neurofibromatosis affect a person’s life?

If there are no complications, the life expectancy of people with NF is almost normal. With the right education, people with NF can live a normal life. Although mental impairment is generally mild, NF1 is a known cause of attention deficit hyperactivity disorder. Learning disabilities are a common problem.

What is the life expectancy of someone with neurofibromatosis type 2?

Tumours that develop inside the brain and spinal cord can place a strain on the body and shorten life expectancy. The average life expectancy for someone with NF2 is 65 years of age. Read more about treating neurofibromatosis type 2.

What are the symptoms of sphenoid dysplasia in adults?

Some degree of cognitive impairment and sometimes mental retardation can be seen in nearly half of patients, even in the absence of other obvious neurological deficits. Short stature, tibial pseudoarthrosis, sphenoid dysplasia, and scoliosis are common. Osteopenia and frank osteoporosis are seen in approximately half of patients.

What do you need to know about sphenoid wing dysplasia?

Sphenoid wing dysplasia 1 Epidemiology. Sphenoid wing dysplasia is seen in 5-10% of cases of NF1 and is one of the diagnostic criteria of NF1 5,6. 2 Pathology. Its exact etiology is not clear. It can be seen isolated or associated with underlying plexiform neurofibroma. 3 Radiographic features 4 See also. Jacquemin C, Bosley TM, Liu D et-al.

Are there any problems with the sphenoid bone?

Disorders or problems of the sphenoid bone can lead to a number of issues, including sphenoid sinusitis (an infection of the sphenoid sinuses), fractures, or sphenoid wing dysplasia—a malformation or deficiency due to a condition called neurofibromatosis type 1. 2 

What kind of structure is the sphenoid bone?

The sphenoid bone has a butterfly-like structure, with four major components—body, lesser wings, greater wings, and pterygoid processes. 1  Located in a central portion that runs along the midline, the body of the sphenoid bone rests between the wings and forms several important structures.