What is an AGEP rash?
Acute generalized exanthematous pustulosis (AGEP) is a severe, usually drug-related reaction, characterized by an acute onset of mainly small non-follicular pustules on an erythematous base and spontaneous resolution usually within two weeks.
How can you tell the difference between pustular and AGEP psoriasis?
In pustular psoriasis, the rash is usually monomorphic, lasts for a longer period of time and is recurrent. It is less flexural than AGEP. Many times it is associated with arthritis and regresses in a period of 10 to 14 days. Histology shows epidermal hyperplasia, papillomatosis and acanthosis2,3.
What does AGEP stand for?
Acute generalised exanthematous pustulosis, or AGEP, is an uncommon pustular drug eruption characterised by superficial pustules. AGEP is usually classified as a severe cutaneous adverse reaction (SCAR) to a prescribed drug. It is also called toxic pustuloderma.
Is AGEP life-threatening?
Unlike Stevens-Johnson syndrome or toxic epidermal necrolysis, AGEP is rarely life-threatening. Systemic involvement is not typical, and if present usually coincides with a mild elevation of the hepatic enzymes and a decrease in renal function.
What is Generalised pustular psoriasis?
Generalized pustular psoriasis (GPP) is a severe form of a skin disorder called psoriasis. GPP and other forms of psoriasis are caused by abnormal inflammation. Inflammation is a normal immune system response to injury and foreign invaders (such as bacteria).
What does Agep look like?
AGEP is characterized by sudden skin eruptions that appear on average five days after a medication is started. These eruptions are pustules, i.e. small red white or red elevations of the skin that contain cloudy or purulent material (pus).
What is impetigo herpetiformis?
Impetigo herpetiformis (IH) is among rare dermatosis of pregnancy, which is currently considered as a form of generalized pustular psoriasis. It is diagnosed by characteristic lesions of erythematous patches and grouped pustules mostly in the third trimester of pregnancy and may have systemic associations.
How do you treat Morbilliform rash?
What is the treatment for morbilliform drug eruption?
- Monitor the patient carefully in case of complications.
- Apply emollients and potent topical steroid creams.
- Consider wet wraps for very red, inflamed skin.
- Antihistamines are often prescribed, but in general they not very helpful.
How is pustular psoriasis diagnosed?
Visit a doctor if you notice unusual skin changes or if you have a rash, blister, or open sore that doesn’t improve or worsens. To diagnose pustular psoriasis, a doctor may perform a complete blood count to check for signs of elevated inflammation and abnormalities in your white blood cells (WBCs).
How serious is pustular psoriasis?
Anyone who has pus-filled bumps over much of the body needs immediate medical care. When widespread, pustular psoriasis can be life-threatening. The pus-filled bumps are called pustules. They can form on the skin, inside the mouth, or beneath a nail.
How to describe the clinical features of AGEP?
In this spectrum there seems to be a subgroup with characteristic clinical features and a typical course which is mostly caused by drugs for which the term acute generalized exanthematous pustulosis (AGEP) has been established. Objective: To describe the clinical features of AGEP.
Can a person get AGEP at any age?
AGEP validation score of the EuroSCAR study group From the current data males and females seem to be equally affected and AGEP can occur at any age.
When does acute generalized exanthematous pustulosis ( AGEP ) occur?
Onset is acute, most often following drug intake, but viral infections can also trigger the disease. Pustules resolve spontaneously in less than 15 days. Conclusion: The diagnosis AGEP should be considered in cases of acute pustular rashes and detection of the causative drug should be strived for.
What’s the difference between AGEP and pustulosis acuta generalisata?
A clear distinction has to be made from the term pustulosis acuta generalisata, which describes a poststreptococcal disease arising mainly in children and different from AGEP. 5 Mostly beginning in the intertriginous areas or in the face a diffuse, often edematous erythema develops very acutely.
