How do you administer INTEGRILIN?
Withdraw the bolus dose(s) of INTEGRILIN from the 10-mL vial into a syringe. Administer the bolus dose(s) by IV push. Immediately following the bolus dose administration, initiate a continuous infusion of INTEGRILIN. When using an intravenous infusion pump, administer INTEGRILIN undiluted directly from the 100-mL vial.
How fast do you push INTEGRILIN?
INTEGRILIN should be given concomitantly with heparin to achieve a target ACT of 200 to 300 seconds. Administer 60-units/kg bolus initially in patients not treated with heparin within 6 hours prior to PCI.
Is INTEGRILIN an anticoagulant?
Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.
When is Integrilin used?
Integrilin is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries).
What is the half life of Integrilin?
The pharmacokinetics of eptifibatide are linear and dose-proportional for bolus doses ranging from 90 to 250 mcg/kg and infusion rates from 0.5 to 3.0 mcg/kg/min. Plasma elimination half- life is approximately 2.5 hours.
What is Integrilin?
Eptifibatide helps to prevent platelets in your blood from sticking together and forming a blood clot. An unwanted blood clot can occur with certain heart or blood vessel conditions.
Is vitamin K an antidote for heparin?
Traditional anticoagulants have antidotes. Heparin can be neutral- ized by protamine, and warfarin anticoagulation can be reversed by vitamin K injections.
What needle do you use for heparin?
The heparin is given by deep subcutaneous injection in the arm or abdomen with a fine needle (25- to 26- gauge) to minimize tissue trauma. A concentrated solution of heparin sodium is recommended.
Why is eptifibatide given by IV?
Eptifibatide reversibly inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive ligands to GP IIb/IIIa. When administered intravenously, eptifibatide inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner.
When to start a continuous infusion of Integrilin?
Immediately following bolus dose administration, initiate a continuous infusion When using an intravenous infusion pump, administer undiluted directly from 100-mL vial Spike the 100-mL vial with a vented infusion set; center the spike within the circle on the stopper top
How many milligrams of Integrilin are in a vial?
INTEGRILIN® (eptifibatide) Injection is supplied as a sterile solution in 10-mL vials containing 20 mg of eptifibatide (NDC 0085-1177-01) and 100-mL vials containing either 75 mg of eptifibatide (NDC 0085-1136-01) or 200 mg of eptifibatide (NDC 0085-1177-02). Vials should be stored refrigerated at 2–8°C (36–46°F).
How much Integrilin should I take before PCI?
Administer 60-units/kg bolus initially in patients not treated with heparin within 6 hours prior to PCI. Additional boluses during PCI to maintain ACT within target. Discontinue administration in patients requiring thrombolytic therapy ACS: 180 mcg/kg IV bolus as soon as possible, THEN continuous infusion 1 mcg/kg/min
Can you use Integrilin in the same line as dextrose?
INTEGRILIN® may be administered in the same IV line with 0.9% NaCl or 0.9% NaCl/5% dextrose. With either vehicle, the infusion may also contain up to 60 mEq/L of potassium chloride. No incompatibilities have been observed with intravenous administration sets.
